Charmaine Aiziva Kahiya

  • Country of Origin: Zimbabwe
  • Home University: Chinhoyi University of Technology
  • Host University & Country: University of Kwazulu-Natal - South Africa
  • PhD Title: Elucidating HIV-1 Integrase Zinc Dependency: Computational Characterization of Metal-Mediated Vulnerabilities Through Advanced Molecular Dynamics for Rational Antiviral Development
  • Year of Completion: 2026
Charmaine Aiziva Kahiya

PhD Overview

HIV-1 continues challenging global health with resistance issues, making new therapeutic approaches crucial. My research investigates HIV-1 integrase’s critical zinc dependency as a novel treatment target. Using advanced computational techniques—steered molecular dynamics, umbrella sampling, and cation dummy approaches—I’m mapping exactly how zinc removal disrupts this essential viral enzyme’s structure and function. This work reveals previously unknown molecular mechanisms and vulnerabilities in HIV-1 replication. These discoveries could guide breakthrough zinc-targeting antiretroviral therapies, offering more effective treatment strategies and new hope for millions living with HIV worldwide.

Sustainability Goals

  • Good Health and Well-being
  • Reduced Inequalities

About Me

Dedicated to breaking barriers for women in science and healthcare. Mandela Washington Fellow (2023) driving STEM equity and education for girls. Through OWSD Zimbabwe leadership and multi-platform mentoring, I champion women’s voices in science while advocating for reproductive health rights. Academic journey: Rhodes BSc, UZ Honours, UKZN MSc, pursuing PhD. Selected for Spark Africa’s inaugural translational medicine cohort, connecting cutting-edge research with real-world impact. Committed to developing life-changing therapies for women and children facing HIV, TB, and cancer.